Similia Similibus Curentur- A Schematic Presentation Of Its Biological Mechanism
BIOLOGICAL MECHANISM INVOLVED IN ‘SIMILIA SIMILIBUS CURENTUR’, AS ENVISAGED BY THE CONCEPTS OF MOLECULAR IMPRINTS THERAPEUTICS COULD BE SCHEMATICALLY EXPLAINED AS FOLLOWS:
Let BIOLOGICAL MOLECULES be represented by ‘M’, and PATHOGENIC MOLECULES by D.
Pathogenic molecule D bind to biological molecule M to form a pathological molecular complex MD. MD represents a pathological molecular error or DISEASE.
Therapeutic process involves with relieving of M from the inhibitions caused by D.
Let crude drug molecules be represented by D1. If D1 can produce symptoms in healthy organism similar to pathological symptoms produced by D, that means D and D1 has similar molecular conformation, so that they could bind to same biological molecules and create similar molecular errors in the organism.
We say D1 is similimum to D, which caused the disease MD.
Molecular imprints of D1 may be represented by ‘d’, with a 3D configuration complementary to D1.
If D1 is siimilimum to D, molecular imprints ‘d’ will be having strong complementary towards D also. That means, ‘d’ can act as ‘artificial binding site’ for D, and selectively bind to it.
When applied as a therapeutic agent, ‘d’ can specifically bind to D of the MD (pathological complex) due to comparatively stronger affinity to form Dd (pathogenic molecule-molecular imprint complex) , thereby relieving M from pathological molecular blocks.
TO SUM UP:
M (biological molecule) +D (pathogenic molecule) > MD (Pathology).
If D1 (drug molecule) is similimum to D (pathogenic molecule), and ‘d’ is ‘molecular imprint’ of D1 (drug molecule),
‘d’ (molecular imprint) will be complementary to D1 (drug molecule) as well as to D (pathogenic molecule).
When ‘d'(molecular imprint) is applied as therapeutic agent,
MD (pathological molecular complex) +d (molecular imprint)> M (free biological molecule) +Dd(pathogenic molecule-molecular imprint complex).
M (biological molecule) is free now (CURE)
Dd ((pathogenic molecule-molecular imprint complex) is now bio-degraded or eliminated from the system
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